Personal information
Buchholz, Frank, Prof. Dr. rer. nat.
NCT/UCC, Medical Systems Biology
Medical Faculty Carl Gustav Carus, TUD
Current position
Professor of Medical Systems Biology (since 2010)
Head of Translational Research, National Center for Tumor Diseases (NCT)/University Cancer Center (UCC)
Role within partner site
Translational research in the field of genome editing and gene therapy
Relevant work experience
Molecular biologist with focus on systems biology and gene editing
2019- Scientific Speaker of the Mildred-Scheel-Nachwuchszentrum Dresden
2017- Member of the Director’s Advisory Board (DAB) of the Institute of Cancer Research, MBICR China
2010- Professor of Medical Systems Biology, TUD
2010- Head of Translational Research, NCT/UCC
2002-10 Group Leader, MPI-CBG Dresden
Professional background
1998-01 Postdoctoral research in the field of Molecular Biology and Genetics, University of California San Francisco
1997-98 Postdoctoral research in the field of Molecular Biology and Genetics, EMBL Heidelberg
1994-97 PhD in Molecular Biology, EMBL Heidelberg
1987-93 Diploma in Molecular Genetics, University of Göttingen and University of California San Diego
Main research focus
Development and implementation of gene editing tools, genome surgery, functional genomics, cancer and viral diseases research
Publications
5 out of 153; SCOPUS h-index 47
Gebler C, …, Buchholz F. Inactivation of Cancer Mutations Utilizing CRISPR/Cas9. J Natl Cancer Inst 2017;109:djw183.
Karpinski J, …, Buchholz F. Directed evolution of a recombinase that excises the provirus of most HIV-1 primary isolates with high specificity. Nat Biotechnol 2016;34:401-9.
Karimova M, …, Buchholz F. Discovery of Nigri/nox and Panto/pox site-specific recombinase systems facilitates advanced genome engineering. Sci Rep 2016;6:30130.
Sarkar I, …, Buchholz F. HIV-1 proviral DNA excision using an evolved recombinase. Science. 2007;316:1912-5.
Buchholz F and Stewart AF. Alteration of Cre recombinase site specificity by substrate-linked protein evolution. Nat Biotechnol 2001;19:1047-52.
Patents
EP2094855, EP2576798, EP2690177, EP1537227, EP1348028, EP1034260, EP1291420, EP2877585, EP17175895
Additional information
GO-Bio Prize, BMBF (2018 & 2008)
ERC Advanced Grant (2018)
Heinz-Ansmann Prize (2017)
EMBO member (2016)
Bayer Healthcare Hemophilia Award (2015)
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