Prof. Dr. rer. nat. Frank Buchholz

Prof. Dr. rer. nat. Frank Buchholz

Personal information

Buchholz, Frank, Prof. Dr. rer. nat.
NCT/UCC, Medical Systems Biology
Medical Faculty Carl Gustav Carus, TUD

Current position

Professor of Medical Systems Biology (since 2010)
Head of Translational Research, National Center for Tumor Diseases (NCT)/University Cancer Center (UCC)

Role within partner site

Translational research in the field of genome editing and gene therapy

Relevant work experience

Molecular biologist with focus on systems biology and gene editing

2019- Scientific Speaker of the Mildred-Scheel-Nachwuchszentrum Dresden

2017- Member of the Director’s Advisory Board (DAB) of the Institute of Cancer Research, MBICR China

2010- Professor of Medical Systems Biology, TUD

2010- Head of Translational Research, NCT/UCC

2002-10 Group Leader, MPI-CBG Dresden

Professional background

1998-01 Postdoctoral research in the field of Molecular Biology and Genetics, University of California San Francisco

1997-98 Postdoctoral research in the field of Molecular Biology and Genetics, EMBL Heidelberg

1994-97 PhD in Molecular Biology, EMBL Heidelberg

1987-93 Diploma in Molecular Genetics, University of Göttingen and University of California San Diego

Main research focus

Development and implementation of gene editing tools, genome surgery, functional genomics, cancer and viral diseases research


5 out of 153; SCOPUS h-index 47

Gebler C, …, Buchholz F. Inactivation of Cancer Mutations Utilizing CRISPR/Cas9. J Natl Cancer Inst 2017;109:djw183.

Karpinski J, …, Buchholz F. Directed evolution of a recombinase that excises the provirus of most HIV-1 primary isolates with high specificity. Nat Biotechnol 2016;34:401-9.

Karimova M, …, Buchholz F. Discovery of Nigri/nox and Panto/pox site-specific recombinase systems facilitates advanced genome engineering. Sci Rep 2016;6:30130.

Sarkar I, …, Buchholz F. HIV-1 proviral DNA excision using an evolved recombinase. Science. 2007;316:1912-5.

Buchholz F and Stewart AF. Alteration of Cre recombinase site specificity by substrate-linked protein evolution. Nat Biotechnol 2001;19:1047-52.


EP2094855, EP2576798, EP2690177, EP1537227, EP1348028, EP1034260, EP1291420, EP2877585, EP17175895

Additional information

GO-Bio Prize, BMBF (2018 & 2008)

ERC Advanced Grant (2018)

Heinz-Ansmann Prize (2017)

EMBO member (2016)

Bayer Healthcare Hemophilia Award (2015)


One Team – One Vision

Prof. Dr. med. Antje Körner
Leipzig University
Department of Pediatrics
Liebigstr. 20a
04103 Leipzig
Phone: +49 341 97 26500

Prof. Dr. med. Reinhard Berner
University Hospital Carl Gustav Carus, TUD
Department of Pediatrics
Fetscherstr. 74
01307 Dresden
Phone: +49 351 458 2440


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