Personal information
Lee-Kirsch, Min Ae, Prof. Dr. med.
Department of Pediatrics
University Hospital Carl Gustav Carus, TUD
Current position
Professor of Molecular Pediatrics (since 2012)
Head of Clinical Research
Role within partner site
Translational research on autoinflammatory and autoimmune diseases, immune dysregulation, immunometabolism
Relevant work experience
Clinical geneticist with focus on type 1-interferonopathies
2020 – Designated speaker, Dresden site, European Reference Network-RITA
2018 – Executive Board, CRC/TRR 237
2017 – Board member, Else-Kröner Research College
2016 – Board member, Maria-Reiche Program for Women
2014 – Vice Speaker, University Center for Rare Diseases
2012 – Professor of Molecular Pediatrics, TUD
2011 – Faculty member, Dresden International Graduate School for Biomedicine and Bioengineering
2010-18 Leader, DFG Clinical Research Unit 249
Professional background
2007 Board certification in Human Genetics, TUD
1999 Board certification in Clinical Molecular Genetics, American Board of Medical Genetics
1995-98 Fellow in Cardiology and Genetics, Harvard Medical School
1986-93 Medical School, University of Heidelberg
Main research focus
Genetics, pathogenesis and therapy of type I interferon-mediated inflammatory disorders, innate immunity, immunometabolism
Publications
5 out of 170; SCOPUS h-index 35
Wolf C, …, Lee-Kirsch MA. Janus kinase inhibition in complement component 1 deficiency. J Allergy Clin Immunol 2020 April 20. doi:10.1016/j.jaci.2020.04.002. Online ahead of print.
Wolf C, …, Lee-Kirsch MA. RPA and Rad51 constitute a cell intrinsic mechanism to protect the cytosol from self DNA. Nat Commun 2016;7:11752.
Günther C, …, Lee-Kirsch MA. Defective removal of ribonucleotides from DNA promotes systemic autoimmunity. J Clin Invest 2015;125:413-24.
Hasan M, …, Lee-Kirsch MA, Yan N. Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes. Nat Immunol 2012;14:61-71.
Lee-Kirsch MA et al. Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 are associated with systemic lupus erythematosus. Nat Genet 2007;39:1065-67. (~400 citations)
Additional information
Wolfgang Schulze Award, Deutsche Rheuma-Liga (2008)
Elected Member, Young Academy, Berlin-Brandenburgische Akademie der Wissenschaften and National Academy of Sciences Leopoldina (2002-2007)
