Prof. Dr. med. Min Ae Lee-Kirsch

Prof. Dr. med. Min Ae Lee-Kirsch

Personal information

Lee-Kirsch, Min Ae, Prof. Dr. med.
Department of Pediatrics
University Hospital Carl Gustav Carus
Technische Universität Dresden (TUD)

Current position

Professor of Molecular Pediatrics (since 2012)
Head of Clinical Research

Role within partner site

Translational research on autoinflammatory and autoimmune diseases, immune dysregulation, immunometabolism;

Relevant work experience

Clinical geneticist with focus on type 1-interferonopathies;

2020– Designated speaker, Dresden site, European Reference Network-RITA

2018– Executive Board, CRC/TRR 237

2017– Board member, Else-Kröner Research College

2016– Board member, Maria-Reiche Program for Women

2014– Vice Speaker, University Center for Rare Diseases

2012– Professor of Molecular Pediatrics, TUD

2011– Faculty member, Dresden International Graduate School for Biomedicine and Bioengineering

2010–2018 Leader, DFG Clinical Research Unit 249

Professional background

2007 Board certification in Human Genetics, TUD

1999 Board certification in Clinical Molecular Genetics, American Board of Medical Genetics

1995–1998 Fellow in Cardiology and Genetics, Harvard Medical School, Boston, MA, USA

1986–1993 Medical School, University of Heidelberg

Main research focus

Genetics, pathogenesis and therapy of type I interferon-mediated inflammatory disorders, innate immunity, immunometabolism;


5 out of 170; SCOPUS h-index 35

Wolf C, …, Lee-Kirsch MA (2020). Janus kinase inhibition in complement component 1 deficiency. J Allergy Clin Immunol 146:1439–1442.

Wolf C, …, Lee-Kirsch MA (2016). RPA and Rad51 constitute a cell intrinsic mechanism to protect the cytosol from self DNA. Nat Commun 7:11752. doi: 10.1038/ncomms11752.

Günther C, …, Lee-Kirsch MA (2015). Defective removal of ribonucleotides from DNA promotes systemic autoimmunity. J Clin Invest 125:413–424.

Hasan M, …, Lee-Kirsch MA, Yan N (2012). Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes. Nat Immunol 14:61–71.

Lee-Kirsch MA et al (2007). Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 are associated with systemic lupus erythematosus. Nat Genet 39:1065–1067. (~400 citations)

Additional information

Awards: Wolfgang Schulze Award, Deutsche Rheuma-Liga (2008);
Elected Memberships: Young Academy, Berlin-Brandenburgische Akademie der Wissenschaften and National Academy of Sciences Leopoldina (2002–2007);


One Team – One Vision

Prof. Dr. med. Antje Körner
Leipzig University
Department of Pediatrics
Liebigstr. 20a
04103 Leipzig
Phone: +49 341 97 26500

Prof. Dr. med. Reinhard Berner
University Hospital Carl Gustav Carus, TUD
Department of Pediatrics
Fetscherstr. 74
01307 Dresden
Phone: +49 351 458 2440


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