Lee-Kirsch, Min Ae, Prof. Dr. med.
Department of Pediatrics
University Hospital Carl Gustav Carus
Technische Universität Dresden (TUD)
Professor of Molecular Pediatrics (since 2012)
Head of Clinical Research
Role within partner site
Translational research on autoinflammatory and autoimmune diseases, immune dysregulation, immunometabolism;
Relevant work experience
Clinical geneticist with focus on type 1-interferonopathies;
2020– Designated speaker, Dresden site, European Reference Network-RITA
2018– Executive Board, CRC/TRR 237
2017– Board member, Else-Kröner Research College
2016– Board member, Maria-Reiche Program for Women
2014– Vice Speaker, University Center for Rare Diseases
2012– Professor of Molecular Pediatrics, TUD
2011– Faculty member, Dresden International Graduate School for Biomedicine and Bioengineering
2010–2018 Leader, DFG Clinical Research Unit 249
2007 Board certification in Human Genetics, TUD
1999 Board certification in Clinical Molecular Genetics, American Board of Medical Genetics
1995–1998 Fellow in Cardiology and Genetics, Harvard Medical School, Boston, MA, USA
1986–1993 Medical School, University of Heidelberg
Main research focus
Genetics, pathogenesis and therapy of type I interferon-mediated inflammatory disorders, innate immunity, immunometabolism;
5 out of 170; SCOPUS h-index 35
Wolf C, …, Lee-Kirsch MA (2020). Janus kinase inhibition in complement component 1 deficiency. J Allergy Clin Immunol 146:1439–1442.
Wolf C, …, Lee-Kirsch MA (2016). RPA and Rad51 constitute a cell intrinsic mechanism to protect the cytosol from self DNA. Nat Commun 7:11752. doi: 10.1038/ncomms11752.
Günther C, …, Lee-Kirsch MA (2015). Defective removal of ribonucleotides from DNA promotes systemic autoimmunity. J Clin Invest 125:413–424.
Hasan M, …, Lee-Kirsch MA, Yan N (2012). Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes. Nat Immunol 14:61–71.
Lee-Kirsch MA et al (2007). Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 are associated with systemic lupus erythematosus. Nat Genet 39:1065–1067. (~400 citations)
Awards: Wolfgang Schulze Award, Deutsche Rheuma-Liga (2008);
Elected Memberships: Young Academy, Berlin-Brandenburgische Akademie der Wissenschaften and National Academy of Sciences Leopoldina (2002–2007);