Pfäffle, Roland, Prof. Dr. med.
Department of Pediatrics, Medical Faculty
Leipzig University (UL)
Professor of Pediatric Endocrinology (since 2002)
Role within partner site
CrescNet registry and combination of etiology, epidemiological screening approaches of growth retardation;
Relevant work experience
Pediatrician scientist in endocrinology;
2010– Chief Scientific Officer of the CrescNet GmbH
1999–2002 Lecturer for Pediatric Endocrinology & Diabetology, RWTH Aachen
1994–2002 Senior Pediatrician, RWTH Aachen
1992– Molecular Biology & Endocrinology Lab (Children’s Hospital, RWTH Aachen, from 2002 at Department of Pediatrics, University Medical Center Leipzig, www.endogenet.org).
1987–1994 Resident in Pediatrics, University Children’s Hospital, RWTH Aachen (paused for Fellowship from 1990–1992)
2006 Certification Child endocrinology and diabetology
1998 Habilitation in Pediatrics (RWTH Aachen, from 2002 in Leipzig)
1994 Board certification in Pediatrics
1990–1992 Visiting Research Fellow, Emory University, Atlanta, Georgia, USA
1989 Foreign Medical Graduate Examination
1988 Research Doctorate (Dr. med., RWTH Aachen)
1980–1986 Medical School, RWTH Aachen
Main research focus
Identification and characterization of transcription factors influencing the human embrionic development of the anterior pituitary; genetic causes of growth retardation with pituitary hormonal deficiency; GH and IGF-1 resistance; long-term effects and safety of treatment with recombinant human growth hormones (rhGH); automation and linkage of auxological screening methods for early detection of childhood disorders of growth and of weight development;
5 out of 131; WOS h-index 27
Felix JF, …, Pfäffle R et al (2016). Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index. Hum Mol Genet 25:389–403.
Blüher S, …, Pfäffle R et al (2011). Age-specific stabilization in obesity prevalence in German children: A cross-sectional study from 1999 to 2008. Int J Pediatr Obes 6:e199–e206.
Abuzzahab MJ, …, Pfäffle R et al (2003). IGF-I receptor mutations resulting in intrauterine and postnatal growth retardation. N Engl J Med 349:2211–2222.
Wu W, … Pfäffle RW et al (1998). Mutations in PROP1 cause familial combined pituitary hormone deficiency. Nat Genet 18:147–149.
Pfäffle R et al (1992). Mutation of the POU-specific domain of PIT-1 and hypopituarism without pituitary hypoplasia. Science 257:1118–1121.
Editorial Board: European Journal of Endocrinology, Journal Paediatric Endocrinology, Zeitschrift für Kinder- und Jugendmedizin;
Awards: Friedrich-Wilhelm-Award for the Habilitation (RWTH Aachen, 1999), Friedrich-Linneweh-Award for Pediatric Research (1992);
Stipends: International Scholarship of the German Research Foundation (1990–1992)