Personal information
Zenclussen, Ana Claudia, Prof.
Department of Environmental Immunology
Helmholtz Centre for Environmental Research – UFZ, Leipzig
Perinatal Immunology Research Group, Saxonian Incubator for Clinical Translation, Medical Faculty
Leipzig University (UL)
Current position
Professor for Environmental Pediatric Immunology, UL (since 2020)
Head of the Department of Environmental Immunology, UFZ (since 2020)
Role within partner site
Effect of environmental exposure during pregnancy on child health, platforms, focused cohorts and experimental models;
Relevant work experience
Immunologist with focus on pregnancy and perinatal immunology;
2007–2020 Professor of Experimental Obstetrics and Gynecology, Medical Faculty, Otto-von-Guericke University Magdeburg
Professional background
2006 Habilitation, Charité-Universitätsmedizin Berlin
2001 PhD in Immunology, Universidad de Buenos Aires, Argentina
1996 Biochemist, Universidad Nacional del Litoral, Argentina
Main research focus
Feto-maternal immune communication, tolerance mechanisms during pregnancy, perinatal exposure to environmental chemicals and long-term consequences for the offspring, hormonal modulation of adaptive immune responses;
Publications
5 out of 131; SCOPUS h-index 40
Busse M, …, Zenclussen AC (2019). IL-10 producing B cells rescue mouse fetuses from inflammation-driven fetal death and are able to modulate T cell immune responses. Sci Rep 9:9335. doi: 10.1038/s41598-019-45860-2.
Meyer N, …, Zenclussen AC (2019). Exposure to 17α-ethinyl estradiol during early pregnancy affects fetal growth and survival in mice. Environ Pollut 251:493–501.
Müller JE, …, Zenclussen AC (2018). Bisphenol A exposure during early pregnancy impairs uterine spiral artery remodeling and provokes intrauterine growth restriction in mice. Sci Rep 8:9196. doi: 10.1038/s41598-018-27575-y.
Schumacher A, …, Zenclussen AC (2013). Human Chorionic Gonadotropin as a central regulator of pregnancy immune tolerance. J Immunol 190:2650–2658.
Zenclussen AC, …, Volk HD (2005). Abormal T cell reactivity against paternal antigens: The adoptive transfer of CD4+CD25+ T regulatory cells prevents fetal rejection in a murine abortion model. Am J Pathol 163:811–822. (~400 citations)
Additional information
Awards: New Investigator Award of the American Society for Reproductive Immunology (2002), GEMI Grant (Harvard/Karolinska) (2007);
Fellowships: Alexander-von-Humboldt Fellowship (2001–2003), Rahel-Hirsch-Habilitation Fellowship (2003–2005);
Societies: Member of numerous Immunology Societies, Education Committee of the American Society for Reproductive Immunology;
Editor: Scientific Reports, Frontiers in Immunology, American Journal of Reproductive Immunology
